The Ceftazidime /Clavulanic Acid – 20 μg Antibiotic Disc – Bioanalyse is a paper disc impregnated with a combination of 20 micrograms of ceftazidime and 10 micrograms of clavulanic acid. Ceftazidime is a third-generation cephalosporin antibiotic, and clavulanic acid is a beta-lactamase inhibitor. Beta-lactamase enzymes are produced by some bacteria to break down cephalosporin antibiotics, making the bacteria resistant to these antibiotics. Clavulanic acid inactivates beta-lactamase enzymes, making ceftazidime more effective against bacteria that produce these enzymes.

The Ceftazidime /Clavulanic Acid – 20 μg Antibiotic Disc – Bioanalyse is used in the disc diffusion method of antimicrobial susceptibility testing to determine the susceptibility of bacteria to ceftazidime/clavulanic acid. The disc diffusion method is a simple and inexpensive method for testing the susceptibility of bacteria to antibiotics. It is based on the principle that bacteria that are susceptible to an antibiotic will not be able to grow near the disc containing the antibiotic.

To perform the disc diffusion test, a bacterial suspension is spread on the surface of an agar plate. Antibiotic discs are then placed on the surface of the agar plate. The plates are incubated for 16-24 hours, and then the zones of inhibition around the discs are measured. The size of the zone of inhibition is proportional to the susceptibility of the bacteria to the antibiotic.

The Ceftazidime /Clavulanic Acid – 20 μg Antibiotic Disc – Bioanalyse is a valuable tool for the diagnosis and treatment of a wide range of bacterial infections, including:

• Community-acquired pneumonia
• Hospital-acquired pneumonia
• Acute otitis media
• Sinusitis
• Urinary tract infections
• Gynecological infections
• Skin and soft tissue infections
• Sepsis
• Meningitis

Interpretation of results:

| Zone of inhibition | Interpretation | |—|—|—| | ≥ 22 mm | Susceptible | | 18-21 mm | Intermediate | | < 18 mm | Resistant |

It is important to note that the disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.

The Ceftazidime /Clavulanic Acid – 20 μg Antibiotic Disc – Bioanalyse is a valuable tool for the diagnosis and treatment of a wide range of bacterial infections. However, it is important to be aware of the potential side effects of ceftazidime/clavulanic acid before using it. Ceftazidime/clavulanic acid can cause side effects such as nausea, vomiting, diarrhea, rash, and allergic reactions. In rare cases, ceftazidime/clavulanic acid can cause serious side effects such as seizures and anaphylaxis.

Limitations of the Ceftazidime /Clavulanic Acid – 20 μg Antibiotic Disc – Bioanalyse:

• The disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.
• The disc diffusion method is not able to detect all bacteria that are resistant to ceftazidime/clavulanic acid. For example, some strains of Pseudomonas aeruginosa are resistant to ceftazidime/clavulanic acid, but they may not produce a zone of inhibition around a ceftazidime/clavulanic acid disc.
• The disc diffusion method can be affected by the type of agar plate used, the incubation temperature, and the inoculum density. Therefore, it is important to follow standardized procedures when performing the disc diffusion test.

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