Trimethoprim/Sulphamethoxazole – 25 μg Antibiotic Disc – Bioanalyse is a paper disc impregnated with 25 micrograms of a combination of trimethoprim and sulfamethoxazole, a broad-spectrum antibiotic. It is used in the disc diffusion method of antimicrobial susceptibility testing to determine the susceptibility of bacteria to trimethoprim/sulfamethoxazole.

Trimethoprim/sulfamethoxazole is a folate antagonist antibiotic, meaning that it works by preventing bacteria from producing the folate they need to grow. It is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. Trimethoprim/sulfamethoxazole is used to treat a variety of infections, including:

• Urinary tract infections
• Respiratory infections
• Skin and soft tissue infections
• Bone and joint infections
• Intra-abdominal infections
• Sepsis
• Meningitis
• Traveler’s diarrhea

Trimethoprim/sulfamethoxazole is also used to prevent infections in people with weakened immune systems, such as those with HIV/AIDS or cancer.

Interpretation of results:

| Zone of inhibition | Interpretation | |—|—|—| | ≥ 16 mm | Susceptible | | 11-15 mm | Intermediate | | < 11 mm | Resistant |

Limitations:

• The disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.
• The disc diffusion method is not able to detect all bacteria that are resistant to trimethoprim/sulfamethoxazole. For example, some strains of Escherichia coli are resistant to trimethoprim/sulfamethoxazole, but they may not produce a zone of inhibition around a trimethoprim/sulfamethoxazole disc.
• The disc diffusion method can be affected by the type of agar plate used, the incubation temperature, and the inoculum density. Therefore, it is important to follow standardized procedures when performing the disc diffusion test.

Important safety information:

• Trimethoprim/sulfamethoxazole is a potent antibiotic, and it can cause a number of side effects, including:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Dizziness
  • Rash
  • Liver damage
  • Blood disorders

• Trimethoprim/sulfamethoxazole can also interact with other medications, so it is important to tell your doctor or pharmacist about all of the medications you are taking before starting trimethoprim/sulfamethoxazole.

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