Trimethoprim – 5 μg Antibiotic Disc – Bioanalyse is a paper disc impregnated with 5 micrograms of trimethoprim, a folate synthesis inhibitor antibiotic. It is used in the disc diffusion method of antimicrobial susceptibility testing to determine the susceptibility of bacteria to trimethoprim.

Trimethoprim is a broad-spectrum antibiotic, meaning that it is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. It is used to treat a variety of infections, including:

• Urinary tract infections
• Respiratory infections
• Skin and soft tissue infections
• Bone and joint infections
• Intra-abdominal infections
• Sepsis
• Meningitis

Trimethoprim is also used to prevent infections before surgery.

Interpretation of results:

Limitations:

• The disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.
• The disc diffusion method is not able to detect all bacteria that are resistant to trimethoprim. For example, some strains of Klebsiella pneumoniae are resistant to trimethoprim, but they may not produce a zone of inhibition around a trimethoprim disc.
• The disc diffusion method can be affected by the type of agar plate used, the incubation temperature, and the inoculum density. Therefore, it is important to follow standardized procedures when performing the disc diffusion test.

Important safety information:

• Trimethoprim is a potent antibiotic, and it can cause a number of side effects, including:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Dizziness
  • Rash
  • Blood cell disorders
  • Allergic reactions, including anaphylaxis

• Trimethoprim can also interact with other medications, so it is important to tell your doctor or pharmacist about all of the medications you are taking before starting trimethoprim.

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