Creatinine j Biochemistry Reagent – Labkit

Creatinine is a break-down product of creatine phosphate in muscle tissue. It is usually produced at a fairly constant rate. Creatinine is cleared by the kidneys with minimal tubular reabsorption. Creatinine accumulates in the blood when GFR decreases in the setting of renal dysfunction. As a result, serum creatinine levels are commonly used as a surrogate for GFR and renal function.

Creatinine is a more reliable indicator of renal function than BUN because it is less influenced by other factors such as diet and hydration. Creatinine together with urea, the most widely known “uremic toxin”, is usually assessed whenever a reduction in kidney function is suspected. This is mainly because creatinine evaluation is cheap, widely accessible and relatively well reflects the renal function. When a renal disorder is suspected, the ratio of BUN to serum creatinine may be useful in diagnosing the location of the problem. A normal ratio is 10–20 mg/dl BUN to 1 mg/dl creatinine. A high (more than 20:1) BUN to creatinine ratio suggests pre-renal disease, whereas a low (less than 10:1) ratio is indicative of renal disease. In the case of renal transplantation, any increase in serum creatinine, as little as it may be, can reflect the rejection of the transplant. An increase of creatinine in serum and urine can be the sign of muscular necrosis. Creatinine is also increased by necrosis or atrophy of skeletal muscle, hyperthyroidism, infections, burns, or fractures.

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