Jaj international CA-15-3 Reagent

CA 15-3 assay values are defined by using the 115D8 and DF3 monoclonal antibodies. Monoclonal antibody 115D8, raised against human milk-fat globule membranes, and monoclonal antibody DF3, raised against a membrane enriched fraction of metastatic human breast carcinoma, react
with epitopes expressed by a family of high molecular weight glycoproteins designated as polymorphic epithelial mucins (PEMs).

Research studies have indicated that CA 15-3 assay values are frequently elevated in patients with breast cancer.7-17 These studies have suggested
that the CA 15-3 assay may be of clinical value for monitoring the response of patients undergoing therapy because increasing and decreasing values
correlated with disease progression and regression, respectively. Additional published studies have suggested that increasing CA 15-3 assay values in patients at risk for breast cancer recurrence after primary therapy may be indicative of recurrent disease before it can be detected clinically. Elevations of CA 15-3 assay values have been reported in individuals with nonmalignant conditions such as cirrhosis, hepatitis, autoimmune disorders, and benign diseases of the ovary and breast.7,8 Non-mammary malignancies in which elevated CA 15-3 assay values have been reported include lung, colon, pancreatic, primary liver, ovarian, cervical, and endometrial.CA 15-3 assay values are not elevated in most normal individuals.The CA 15-3 assay is not recommended as a screening procedure to detect cancer in the general population; however, use of the CA 15-3 assay as an aid in the management of breast cancer patients has been reported.

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