IL-6 Fast Test Kit (Immunofluorescence Assay

Intended Use

IL-6 Fast Test Kit (Immunofluorescence Assay) is intended for in vitro quantitative determination of interleukin 6 (IL-6) in human serum, plasma, whole blood and peripheral blood samples. IL-6 is an early marker in acute inflammation and this test can be used as an aid in the inflammatory diseases.

About IL-6

IL-6 is a cytokine that functions in inflammation and maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response. This classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kDa cognate Alpha-chain (IL-6R Alpha), and a ubiquitously expressed 130-kDa Beta-chain receptor (gp130) which acts as the universal signal transducing element for all IL-6 family cytokines.

Many different cells are capable of IL-6 synthesis including monocytes/macrophages, fibroblasts, endothelial cells, keratinocytes, mast cells, T cells and many tumor cell lines. In vivo and in vitro, IL-6 acts as a differentiation factor for B cells and an activation factor for T cells.

IL-6 is a potent growth factor of different human myelomas and is active in concentrations less than 10 pg/mL. IL-3 and IL-6 show in vitro synergistic effects in the differentiation of hematopoietic progenitor cells. Elevated IL-6 serum or plasma levels may occur in different diseases including sepsis, autoimmune diseases, lymphomas, AIDS, alcoholic liver disease and in patients with infections, or transplant rejection.

Contents

1. For Getein1100:

Package specifications: 25 tests/box, 10 tests/box

1) Getein IL-6 test card in a sealed pouch with desiccant

2) Disposable pipet

3) User manual: 1 piece/box

4) SD/RFID card: 1 piece/box

5) Whole blood buffer: 1 bottle/box

2. For Getein1600:

Package specifications: 2×24 tests/kit, 2×48 tests/kit

1) Sealed cartridge with 24/48 Getein IL-6 test cards

2) User manual: 1 piece/box

Materials required for Getein1600:

1) Sample diluent: 1 bottle/box

2) Box with pipette tips: 96 tips/box

3) Mixing plate: 1 piece/box

Note: Do not mix or interchange different batches of kit