HbcAb (Anti-Hbc) Total Reagent Jaj international

The HBcAb IgM ELISA is an enzyme-linked immunosorbent assay for the qualitative identification of IgM class antibodies to hepatitis B core antigen in human serum/plasma. The HBcAb IgM ELISA test result is an aid for clinical lab diagnosis of hepatitis B infected patients.

Description

HBcAb IgM ELISA test Background Information :
As part of the Hepadnaviridae family, HBV is an enveloped, double-stranded DNA virus that is a primary cause of hepatitis transmission through blood. In order to classify hepatitis B infection, the serological markers need to be identified during the three phases of the infection – incubation, acute, and convalescent. The main component of the virus is Hepatitis B core antigen (HBcAg).

This core antigen is comprised of a single polypeptide of approximately 17kD that is discharged upon disaggregation of the core particles. At least one immunological determinant is present in the antigen. Shortly after the onset of HBsAg, antibodies to HBcAg (anti-HBc total antibody and IgM) appear and are always present. In isolated cases, a Hepatitis B infection can be contracted without immunologically detectable anti-HBc. This is found usually in immunosuppressed patients. During the acute stages of hepatitis infection, particles of anti-HBc IgM synthesis are detectable.

This presence confirms reactivation of HBV in hepatocites and causes permanent IgM low titers. The presence of IgM and total anti-HBc signifies a recent or ongoing HBV infection. A laboratory diagnosis, or a confirmation of a negative HBV infection, can be reached when this test is performed concurrently with tests for other HBV serological markers.

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