The ENZO TB-IGRA Hormone Test Kit is a quantitative enzyme-linked immunosorbent assay (ELISA) for the detection of interferon-gamma (IFN-γ) release in response to exposure to Mycobacterium tuberculosis (Mtb) antigens in whole blood. The kit is intended for in vitro diagnostic use as an aid in the diagnosis of tuberculosis (TB) infection.

TB infection is caused by inhalation of the Mtb bacteria. It is different from TB disease, which is the active form of TB infection and can cause symptoms such as cough, fever, and night sweats. Most people who are infected with Mtb do not develop TB disease. However, people with TB infection are at risk of developing TB disease, especially if they are immunocompromised or have other risk factors.

The ENZO TB-IGRA Hormone Test Kit can be used to diagnose TB infection in people of all ages, including children and pregnant women. It is a more specific test than the traditional tuberculin skin test (TST), and it is less likely to be affected by previous BCG vaccination or non-tuberculous mycobacteria (NTM) infection.

The test is performed by collecting a blood sample from the patient and incubating it with Mtb antigens. If the patient has been infected with Mtb, their white blood cells will release IFN-γ in response to the antigens. The amount of IFN-γ released is measured using the ELISA test. A high level of IFN-γ indicates that the patient is likely infected with Mtb.

The ENZO TB-IGRA Hormone Test Kit is a valuable tool for the diagnosis of TB infection. It is a sensitive and specific test that can be used to identify people who are at risk of developing TB disease.

Clinical significance of a positive TB-IGRA test result:

A positive TB-IGRA test result indicates that the person is likely infected with Mtb. This does not necessarily mean that the person has TB disease. However, people with a positive TB-IGRA test result should be evaluated for TB disease, especially if they have risk factors such as HIV infection, recent contact with a person with TB disease, or a history of TB disease.

When to order a TB-IGRA test:

A TB-IGRA test is typically ordered for people who have symptoms of TB disease, such as cough, fever, and night sweats. It is also ordered for people who have risk factors for TB infection, such as HIV infection, recent contact with a person with TB disease, or a history of TB disease.

How to interpret a TB-IGRA test result:

A positive TB-IGRA test result indicates that the person is likely infected with Mtb. This does not necessarily mean that the person has TB disease. However, people with a positive TB-IGRA test result should be evaluated for TB disease.

A negative TB-IGRA test result indicates that the person is unlikely to be infected with Mtb. However, people with a negative TB-IGRA test result who have risk factors for TB infection may need to be retested in the future.

It is important to note that the TB-IGRA test is not a perfect test. There can be false positive and false negative results. Therefore, it is important to consider the patient’s clinical history and risk factors when interpreting a TB-IGRA test result.

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