DHEA’S Reagent – Jaj International

Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant steroid hormones in the human bloodstream. Blood levels are highest in the developing foetus, drop sharply after birth, begin climbing again at age 6-8 (a time of rapid growth) to a peak at age 25-30 and then decline to about 10% of the peak level by age 80. Adult blood levels of DHEAS are 100-500 times higher than testosterone and 1,000-10,000 times higher than estradiol. DHEA circulates in the bloodstream mainly as the sulfated form, DHEAS.

The half-life of DHEAS is 7-10 hours, whereas the half-life of DHEA is only 15-30 minutes. HEAS is converted to DHEA and then to sex hormones in body tissues. No change in DHEAS serum levels is seen beyond the age of 90, and men over 90 with the highest serum DHEAS levels show the best functional status.

With the exception of high-affinity G-protein DHEA receptors on endothelial cells, there are no receptors for DHEA, which some have interpreted as meaning that it serves mainly as a precursor to other hormones. A sense of futility (or acceptance) concerning aging-associated functional decline, the diversity & vaguely-understood nature of DHEA actions and the fact that DHEA is a natural hormone that cannot be patented have all contributed to the relative lack of research that has been done on the value of DHEA hormone replacement.

About half of the body’s DHEA is produced in the adrenal cortex — with the rest coming from gonads, fat tissue and (notably) the brain. Sex hormones are produced almost exclusively by the ovary &
testes of most mammals, whereas for humans (and to a lesser extent some other primates) about half of the sex hormones come from the gonads and about half is synthesized on an as-needed basis from DHEA in peripheral tissues (breast, prostate, brain, muscle, liver, etc.) For post-menopausal women, DHEA is the only source of sex hormones in peripheral tissues.

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