HCV (Anti- HCV) Reagent – Jaj International

Description

Anti-HCV assay is a chemiluminescent microparticle immunoassay (CMIA) for the qualitative detection of antibody to hepatitis C virus (anti-HCV) in human serum and plasma.

Anti-HCV assay is for the detection of antibodies to hepatitis C virus (HCV). Chemiluminescent immunoassays are a variation of the enzyme immunoassay (EIA) principle. Solid phase EIAs, first described in the early 1970s, use antigens and/or antibodies coated on a surface to bind complementary analytes.1 The bound analyte is detected by a series of antigen-antibody reactions. EIAs are available to identify antigens and
antibodies related to viral hepatitis infection.

In the ARCHITECT Anti-HCV final reaction, bound acridinylated conjugates are used to generate achemiluminescent signal. HCV is a bloodborne virus.2,3 Serological studies employing EIAs for detection of antibodies to recombinant antigens of HCV have established HCV as the cause of most bloodborne4-9 as well as community-acquired10 non-A, non-B hepatitis. The presence of anti-HCV indicates that an individual may have been infected with HCV, may harbor infectious HCV, and/ or may be capable of transmitting HCV infection.

11 Although the majority of infected individuals may be asymptomatic, HCV infection may develop into chronic hepatitis, cirrhosis, and/or increased risk of hepatocellular carcinoma.12-15 The implementation of blood donation screening for anti-HCV by EIAs has led to a marked decline in the risk of transfusion transmitted hepatitis.1

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